Table 3. Association between mbl2 exon1 polymorphisms and the persistence of HBV infection in different ethnicity-subgroups.
| No. studies |
OR* for variant genotype (95% CI)
|
Test for heterogeneity P value | I2 | ||
|---|---|---|---|---|---|
| Healthy controls | |||||
| Asian | |||||
| AO/OO vs AA | 6 | 1.08 | 0.82-1.42 | 0.156 | 37.6% |
| AO vs AA | 4 | 1.13 | 0.83-1.55 | 0.054 | 60.7% |
| OO vs AA | 4 | 0.90 | 0.35-2.32 | − | − |
| OO vs AO/AA | 4 | 0.98 | 0.38-2.50 | − | − |
| Non-Asian | |||||
| AO/OO vs AA | 5 | 1.18 | 0.92-1.51 | 0.899 | 0.0% |
| AO vs AA | 4 | 1.16 | 0.90-1.50 | 0.934 | 0.0% |
| OO vs AA | 4 | 1.28 | 0.76-2.16 | 0.927 | 0.0% |
| OO vs AO/AA | 4 | 1.20 | 0.72-1.99 | 0.947 | 0.0% |
| Spontaneous recovered controls | |||||
| Asian | |||||
| AO/OO vs AA | 3 | 1.15 | 0.88-1.49 | 0.120 | 52.9% |
| AO vs AA | 3 | 0.89 | 0.68-1.16 | 0.080 | 60.5% |
| OO vs AA | 3 | 0.77 | 0.37-1.59 | 0.788 | 0.0% |
| OO vs AO/AA | 3 | 0.80 | 0.39-1.64 | 0.604 | 0.0% |
| Non-Asian | |||||
| AO/OO vs AA | 5 | 1.00 | 0.75-1.32 | 0.561 | 0.0% |
| AO vs AA | 4 | 1.17 | 0.81-1.68 | 0.691 | 0.0% |
| OO vs AA | 4 | 1.32 | 0.63-2.76 | 0.807 | 0.0% |
| OO vs AO/AA | 4 | 1.27 | 0.62-2.60 | 0.688 | 0.0% |
OR: odds ratio; CI: confidence interval; −: can’t be calculated. “AO/OO vs. AA”: “Dominant model”; “OO vs. AO/AA”: “Recessive model”; “AO vs. AA” and “OO vs. AA”: “Co-dominant model.