. 2013 Sep 27;9:535–549. doi: 10.2147/VHRM.S44568

Table 4.

Changes in ambulatory blood pressure monitoring data in the two treatment groups

Patterns	Losartan + HCTZ			Bisoprolol + HCTZ
Patterns	Baseline	3 months	6 months	Baselines	3 months	6 months
Maximum 24-hour SBP, mmHg	184.7 ± 8.1	173.8 ± 14.7	158.2 ± 4.1^*	188.8 ± 6.4	174.8 ± 6.8	161.7 ± 6.7^*
Maximum 24-hour DBP, mmHg	113.2 ± 3.8	102.6 ± 7.2^***	103.3 ± 2.9^***	111.4 ± 7.3	112.8 ± 5.6	110.1 ± 6.5
24-hour pulse pressure, mmHg	59.3 ± 2.8	59.9 ± 4.6	51.3 ± 3.1	53.8 ± 2.4	51.2 ± 6.5	48.7 ± 2.9
Daily index SBP, %	7.9 ± 1.6	8.7 ± 1.5	7.9 ± 1.7	9.5 ± 2.3	8.9 ± 1.5	7.2 ± 1.8
Daily index DBP, %	11.4 ± 1.9	13.6 ± 2.2	12.0 ± 1.6	11.7 ± 1.9	11.5 ± 2.3	12.8 ± 2.8
Pressure load, 24-hour SBP, %	69.0 ± 5.4	49.5 ± 6.9^***	23.7 ± 4.5^*	74.7 ± 5.6	56.4 ± 7.5^*	25.9 ± 7.4^*
Pressure load, 24-hour DBP, %	44.2 ± 6.5	21.9 ± 6.0^**	13.1 ± 2.8^*	58.8 ± 9.9	35.9 ± 8.1^**	15.1 ± 6.1^*
Daytime SBP, mmHg	148.9 ± 3.5	137.3 ± 3.1^**	125.9 ± 2.6^*,^{^}	151.1 ± 4.2	140.3 ± 4.1	125.8 ± 4.1^*,^{^^}
Daytime DBP, mmHg	97.1 ± 2.6	80.9 ± 2.9^*	75.2 ± 1.8^*	95.2 ± 4.0	85.7 ± 3.5	78.4 ± 2.7^*
Daytime HR, beats per minute	72.9 ± 2.0	77.3 ± 2.9	78.0 ± 2.5	83.9 ± 3.5^#	76.3 ± 3.8	77.6 ± 3.3
Daytime pulse pressure, mmHg	58.7 ± 2.6	62.3 ± 5.9	50.7 ± 2.2^***	54.6 ± 2.6	54.6 ± 3.4	47.4 ± 2.0
Daytime SBP variability, mmHg	16.7 ± 0.9	13.2 ± 0.8^*	13.7 ± 0.9^***	16.6 ± 1.3	13.8 ± 1.0	14.5 ± 1.8
Daytime DBP variability, mmHg	12.3 ± 0.7	10.9 ± 0.7	10.7 ± 0.7	11.6 ± 1.1	10.4 ± 0.6	12.4 ± 1.2
Pressure load, daytime SBP, %	63.5 ± 6.0	46.1 ± 7.7	17.2 ± 4.7^*,^{^}	68.9 ± 6.7	47.9 ± 8.1	20.7 ± 8.4^*,^{^^}
Pressure load, daytime DBP, %	44.0 ± 6.3	23.2 ± 7.2^***	12.3 ± 2.9^*	60.4 ± 9.7	36.6 ± 9.0	18.4 ± 7.1^*
Nighttime SBP, mmHg	136.5 ± 4.5	125.8 ± 3.1	117.3 ± 3.5^*	140.1 ± 4.1	130.7 ± 3.7	117.3 ± 4.2^*,^{^^}
Nighttime DBP, mmHg	83.4 ± 2.7	69.9 ± 1.9^*	66.0 ± 1.5^*	85.9 ± 3.5	75.3 ± 2.6^***,^#	66.9 ± 2.7^*
Nighttime pulse pressure, mmHg	60.1 ± 3.7	56.4 ± 3.1	51.3 ± 2.7	52.0 ± 2.9	55.4 ± 3.4	50.4 ± 2.6
Nighttime HR, beats per minute	74.8 ± 3.3	67.6 ± 2.5	69.3 ± 2.5	78.2 ± 3.8	65.6 ± 3.8	67.5 ± 2.1^***
Nighttime SBP variability, mmHg	15.9 ± 1.5	12.7 ± 1.3	13.6 ± 1.1	11.9 ± 1.3^#	14.8 ± 1.6	12.6 ± 2.1
Nighttime DBP variability, mmHg	10.4 ± 0.8	9.2 ± 0.8	10.3 ± 0.9	8.4 ± 1.2	10.4 ± 1.6	9.6 ± 1.3
Pressure load, nighttime SBP, %	73.5 ± 6.2	54.1 ± 7.6	37.4 ± 6.5^*	85.1 ± 5.2	71.1 ± 8.4	36.2 ± 10.1^*
Pressure load, nighttime DBP, %	33.7 ± 7.1	15.7 ± 5.1^***	11.7 ± 3.2^*	60.4 ± 8.9	33.6 ± 7.7^***	10.6 ± 6.7^*
Morning surge SBP, mmHg	65.6 ± 6.6	43.6 ± 5.5^**	42.1 ± 2.6^*	67.7 ± 6.5	48.3 ± 5.6^***	38.7 ± 6.0^**
Morning surge DBP, mmHg	35.4 ± 5.9	26.1 ± 4.7	33.8 ± 2.5	33.7 ± 4.3	34.7 ± 4.0	29.3 ± 5.6
Target 24-hour BP, n (%)	–	20 (62.5)	24 (75.0)^{^}	–	14 (51.9)	18 (66.7)^{^^}

Notes:

P < 0.01;

^**

P < 0.02;

^***

P < 0.05 versus baseline in same group;

^{^}

P < 0.01;

^{^^}

P < 0.05 versus month 3 in same group;

P < 0.05 versus losartan + HCTZ group.

Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure; HCTZ, hydrochlorothiazide; HR, heart rate.