Table 2. Risk Factors Associated with Early Mortality Compared to Survival in Patients with IPD in Calgary.

Risk Factor	Risk Factor Sub-category	RRR of Early Mortality to Survival (95% CI)a	P-value
Disease Severity	Less Severe Disease	Reference group
	More Severe Disease	13.7 (3.3-56.9)	<0.001
Comorbidities	Charlson comorbidity index=0	Reference group
	Charlson comorbidity index=1	2.6 (0.7-10.4)	0.164
	Charlson comorbidity index≥2	6.3 (1.8-21.9)	0.004
Age	Per 5 year increase	1.3 (1.2-1.4)	<0.001
Gender	Female	Reference Group
	Male	0.6 (0.3-0.9)	0.03
Primary Diagnosis	Bacteremia/Other Invasive	Reference group
	Pneumonia/Empyema	0.5 (0.3-1.2)	0.115
	Meningitis	1.7 (0.5-5.4)	0.369
Time to receipt of appropriate antibiotic treatment	<24 hours post-presentation	Reference group
	24-48 hours post-presentation	1.0 (0.3-3.2)	0.948
	>48 hours post-presentation	-b	-a
	No receipt of appropriate antibiotics	5.6 (2.4-13.1)	<0.001

a RRR=Relative Risk Ratio 95% CI = 95% Confidence Interval; b. No inferences can be made with this estimate due to a zero cell.