Table 3. Risk Factors Associated with Late Mortality Compared to Survival in Patients with IPD in Calgary.

Risk Factor	Risk Factor Sub-category	RRR Late Mortality to Survival (95% CI)a	P-value
Disease Severity Modified by Comorbidities	Less severe disease and Charlson comorbidity index =0	Reference group
	More severe disease and Charlson comorbidity index=0	21.1 (4.2-105.7)	<0.001
	Less severe disease and Charlson comorbidity index=1	-b	-a
	More severe disease and Charlson comorbidity index =1	22.6 (4.5-113.9)	<0.001
	Less severe disease and Charlson comorbidity index ≥2	6.1 (1.4-27.7)	0.018
	More severe disease and Charlson comorbidity index ≥2	22.4 (4.8-103.9)	<0.001
Age	Per 5 year increase	1.3 (1.1-1.4)	<0.001
Gender	Female	Reference group
	Male	0.6 (0.3-1.2)	0.163
Primary Diagnosis	Bacteremia/other invasive diagnosis	Reference group
	Pneumonia/empyema diagnosis	1.0 (0.3-3.1)	0.990
	Meningitis	3.3 (0.8-14.1)	0.099
Time to receipt of appropriate antibiotic treatment	<24 hours post-presentation	Reference group
	24-48 hours post-presentation	1.2 (0.3-4.3)	0.776
	>48 hours post-presentation	1.6 (0.4-6.1)	0.463
	No receipt of appropriate antibiotics	0.8 (0.1-6.7)	0.863

a RRR=Relative Risk Ratio 95% CI = 95% Confidence Interval; b. No inferences can be made with this estimate due to a zero cell.