Figure 1.

Twenty-eight-day mortality according to stratification of the vancomycin AUC/MIC values in severe hypoalbuminemia and non-severe hypoalbuminemia groups. (A) AUC/MIC <250 μg × h/ml, (B) AUC/MIC = 250–450 μg × h/ml, and (C) AUC/MIC >450 μg × h/ml. P-values were determined using χ² tests. The AUC values of 250–450 and >450 μg × h/mL were significantly associated with 28-day mortality in patients with severe hypoalbuminemia (**P < 0.001), while AUC values of <250 μg × h/ml were not (P = 0.143).

Abbreviations: AUC, area under the concentration curve; MIC, minimum inhibitory concentration.