Figure 2.

Schematic presentation of the domain structure of Ca²⁺/CaM-regulated protein kinases. One example of each class of CaM-regulated kinases, MtCCaMK (UniProt Q6RET7), AtCBK3/AtCRK1 (UniProt O80673), AtCRCK1 (UniProt Q9FIL7), AtCRLK1 (UniProt Q9FIU5), and AtMPK8 (UniProt Q9LM33), is presented. The kinase domain is in blue, CaMBD is in red, functional EF hands are in bright purple and degenerated EF hands are in light purple, the transmembrane domain is in light brown, and the yellow bar in MAPK8 represents the conserved TDY motif recognized and phosphorylated by MAPK kinases. CaMBDs in the MAPK D subgroup, including MPK8, are not currently resolved.