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. 2013 Oct 9;7:161. doi: 10.3389/fncir.2013.00161

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Copyright © 2013 Papoutsi, Sidiropoulou, Cutsuridis and Poirazi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dependence of microcircuit spiking activity on stimulus-specific parameters. (A) Graph showing the effect of stimulus frequency (20, 50, 100 Hz) on the probability of persistent activity initiation. Parameters used: iNMDA-to-iAMPA ratio = 2.3, iGABA_B-to-iGABA_A ratio = 0.4, dADP deactivated. (B) Graph showing the effect of stimulus Duration (250 ms, 500 ms, 750 ms, 1 s) on the probability of persistent activity initiation. Parameters used: iNMDA-to-iAMPA ratio = 2.3, iGABA_B-to-iGABA_A ratio = 0.4, dADP deactivated. (C) Indicative voltage trace showing the effect of a second excitatory stimulus (100 Hz, 10 events) to the pyramidal neurons. Bars indicate stimulus presentation times.