Figure 4.

Intrinsic conductances modulate persistent activity induction. (A) Bar graph showing the effect on induction probability when the conductance of the various currents is reduced to 10% of its control value (iNMDA-to-iAMPA = 2.3, iGABA_B-to-iGABA_A ratio = 0.4, dADP deactivated). (B) Bar graph showing the normalized change in intracellular calcium concentration (measured as the integral over the inducing stimulus period) with respect to the control value when L, N or R type calcium channels are blocked. (C) Bar graph showing the normalized change in the slow AHP current (measured as the integral over the inducing stimulus period) with respect to the control value when L, N or R type calcium channels are blocked. (D) Bar graph showing the normalized change in the fast AHP current (measured as the integral over the inducing stimulus period) with respect to the control value when L, N or R type calcium channels are blocked. In all cases, error bars correspond to standard error. ^**p < 0.01; ^***p < 0.001.