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. 2013 Oct 9;7:161. doi: 10.3389/fncir.2013.00161

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Copyright © 2013 Papoutsi, Sidiropoulou, Cutsuridis and Poirazi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synaptic conductances gate and modulate the persistent excitable states. (A) Box plot of ISI distributions recorded in a single pyramidal neuron for dADP values 0, 2, and 4 mV. (B) Box plot of ISI distributions recorded in a single pyramidal neuron for iNMDA-to-iAMPA ratio 1.5, 1.9, 2.3. (C) Box plot of ISI distributions recorded in a single pyramidal neuron for iGABA_B-to-iGABA_A values 0.2, 0.4, 0.6. (D) Probability of sustained activity emergence in the microcircuit as a function of the iGABA_B-to-iGABA_A ratio (iNMDA-to-iAMPA = 2.3, dADP = 0 mV). (E) 2-D contour plot showing the combined effects of the dADP mechanism (0–6 mV) and the iNMDA-to-iAMPA ratio (1.1–2.3) on the probability of persistent activity induction. Blue: failure of induction, red: induction in 100% of the trials (iGABA_B-to-iGABA_A ratio = 0.4).