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. 2004 Apr 1;113(7):1017–1024. doi: 10.1172/JCI20007

Figure 7.

Figure 7

Liver necrosis induced by uncontrolled transcription of the Fas-c transgene. Liver sections of tumor-bearing mice demonstrate the nonspecific activity of Ad-CMV-Fas-c (B), compared with Ad-PPE-Fas-c (A). LLC lung metastases were created in 90 male mice, as before. Ad-PPE-Fas-c, Ad-CMV-Fas-c, Ad-PPE-luc, or saline was injected i.v. twice, 5 and 14 days after tumor resection, with human TNF-α (1 μg/mouse). Ten days later, mice were sacrificed and livers were stained. Arrow: broad necrotic area in Ad-CMV-Fas-c–injected mouse. ×200.