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. 2013 Oct 9;3:261. doi: 10.3389/fonc.2013.00261

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Copyright © 2013 Jakopovic, Thomas, Balasubramaniam, Schrump, Giaccone and Bates.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lung carcinoma cells treated with HDAC inhibitors. Dose response studies of cell cycle following 24 h treatment with either romidepsin (DEPSI) or vorinostat (SAHA) are show in the histograms. Concentrations are shown in the legend and represent equipotent concentrations for growth inhibition (Luchenko et al., manuscript in preparation). The NSCLC cell line responds to the HDAC inhibitor with G2 arrest and loss of the G1 peak, while the SCLC line H526 responds with both G1 and G2 arrests and apoptosis.