Table 1. IC50 values of fatty acids for estradiol 3-O-glucuronidation.
Fatty acids | IC50 values |
---|---|
Oleic acid | 31.6 μM |
Linoleic acid | 33.1 μM |
Palmitoleic acid | 37.1 μM |
Alpha-linolenic acid | 26.1 μM |
Arachidonic acid | 22.7 μM |
DHA | 11.6 μM |
EPA | 19.9 μM |
IC50 values were directly determined in the UGT1A1 recombinant system from linear regression (Fig. 1). IC50 values of stearic acid, myristic acid, lauric acid, palmitic acid, behenic acid, arachidic acid, lignoceric acid, and decanoic acid were more than 50 μM.