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. 2013 Oct 9;3:2903. doi: 10.1038/srep02903

Table 1. IC50 values of fatty acids for estradiol 3-O-glucuronidation.

Fatty acids IC50 values
Oleic acid 31.6 μM
Linoleic acid 33.1 μM
Palmitoleic acid 37.1 μM
Alpha-linolenic acid 26.1 μM
Arachidonic acid 22.7 μM
DHA 11.6 μM
EPA 19.9 μM

IC50 values were directly determined in the UGT1A1 recombinant system from linear regression (Fig. 1). IC50 values of stearic acid, myristic acid, lauric acid, palmitic acid, behenic acid, arachidic acid, lignoceric acid, and decanoic acid were more than 50 μM.