Table 2. K_i values of fatty acids for estradiol 3-O-glucuronidation.

Fatty acids	Ki values
Recombinant UGT1A1
Oleic acid	23.4 μM
Linoleic acid	22.1 μM
DHA	1.8 μM
Human liver microsomes
Oleic acid	29.3 μM
Linoleic acid	24.0 μM
DHA	4.3 μM
Human small intestine microsomes
Oleic acid	-
Linoleic acid	-
DHA	5.2 μM

K_i values were determined in the UGT1A1 recombinant system and liver microsomes of the human liver and small intestine (Fig. 2–4).