Figure 6.

Development (A) and morphology (B) of the forelimb, and the representation of the forelimb in somatosensory cortex (C) in mice and bats. (A) At middle stages of forelimb development the expression of Prx1 (purple) is expanded in the distal forelimb (red arrows). This alteration, among a number of other molecular changes, accounts for the radical differences in the rat forepaw compared to the bat wing (B). These morphological differences in the distal forelimb in addition to differential use of the paw vs. wing have likely contributed to the differences in size and internal organization of the forelimb representation in S1 (C). Figures are modified from Cretekos et al. (2001, 2008); Woolsey (1967), and Wise et al. (1986). Other conventions as in previous figures.