Table 1.
Description of Recent and Chronic Acetaminophen Exposure Measures
| APAP use measure |
Definition/Description | Categories | Reference group |
|---|---|---|---|
| Recent APAP exposure measures : measured in the 7 days pre-index | |||
| APAP exposure in the 7 day pre-index period |
Use of an APAP containing prescription for at least one day in the 7 days pre-index period |
Yes/No | No APAP exposure in the 7 day pre-index period |
| Potential Maximum daily dose (PMDD) in the 7 day pre- index period |
The highest potential APAP dose on any day during the 7 days pre-index. Calculated using the days-supplied, strength, and quantity fields in the data. Overlapping prescriptions were identified using fill-dates and days-supplied and the daily doses were summed to obtain the PMDD. |
PMDD <= 4gm/day PMDD > 4gm/day |
No APAP use (PMDD = 0 gm/day) |
| Recent APAP exposure measures : measured in the 30 days pre-index | |||
| APAP exposure in the 30 days pre- index period |
Use of an APAP containing prescription for at least one day in the 30 day pre-index period |
Yes/No | No APAP exposure in the 30 days pre-index period |
| Potential Maximum daily dose (PMDD) in the 30 days pre- Index |
The highest potential APAP dose on any day during the 30 days pre- index. Calculated using the days- supplied, strength, and quantity fields in the data. Overlapping prescriptions were identified using fill-dates and days-supplied and the daily doses were summed to obtain the PMDD. |
PMDD <= 4gm/day PMDD > 4gm/day |
No APAP use (PMDD = 0 gm/day) |
| Potential average daily dose (PADD) in the pre-index month |
Dose obtained by summing up the APAP doses contained in all prescriptions in the 30 days pre- index and dividing by the total days of APAP use in the 30 days pre- index period. |
PADD <= 4gm/day PADD > 4gm/day |
No APAP use (PADD = 0 gm/day) |
| Chronic APAP exposure measures : measured in the pre-index year | |||
| Cumulative dose (CD) for one year pre-index |
Sum of APAP doses in all APAP containing prescriptions in the pre- index year |
CD <= 1kg CD > 1kg |
No APAP use (CD = 0 kg) |
| Duration of APAP use |
Total number of days of APAP use in the pre-index year |
1 to 30 days 31 to 365 days |
No APAP use |
| Combination of dose and duration of APAP use |
Joint effect of APAP dose and duration of APAP use in the pre- index year |
PMDD <= 4gm/day & duration <= 30 days PMDD <= 4gm/day & duration > 30 days PMDD > 4gm/day & duration <= 30 days PMDD > 4gm/day & duration > 30 days |
No APAP use (PMDD = 0 and duration = 0) |
APAP : Acetaminophen; CD: Cumulative dose; PADD: Potential average daily dose; PMDD: potential maximum daily dose