Table 3.
Prescription Acquired Acetaminophen Exposure, Doses and Durations of Use for Asthma Cases and Matched Controls in the Pre-Index Period
| Variable | Cases | Controls | ||
|---|---|---|---|---|
| N = 28,892 | N = 86,676 | |||
| Acetaminophen exposure variables | ||||
| APAP exposure for at least one day - 7 days (n,%) | 798 | 2.8% | 1721 | 2.0% |
| APAP exposure for at least one day - 30 days (n,%) | 1415 | 4.9% | 3271 | 3.8% |
| APAP exposure for at least one day – 365 days (n,%) | 6537 | 22.6% | 15809 | 18.2% |
| Maximum daily dose in the 7 days pre-index | ||||
| MDD (mg) - 7 days (Mean a, SD) | 3004.4 | 4871.3 | 2947.2 | 7533.1 |
| MDD (<= 4gm/day) - 7 days (n,%) | 690 | 2.4% | 1486 | 1.7% |
| MDD (> 4gm/day) - 7 days (n,%) | 108 | 0.4% | 235 | 0.3% |
| Maximum daily dose in the 30 days pre-index | ||||
| MDD (mg) - 30 days (Mean b†, SD) | 3393.5 | 5219.0 | 3346.4 | 6279.2 |
| MDD (<= 4gm/day) - 30 days (n,%) | 1148 | 4.0% | 2632 | 3.0% |
| MDD (> 4gm/day) - 30 days (n,%) | 267 | 0.9% | 639 | 0.7% |
| Average daily dose in the 30 days pre-index | ||||
| ADD (mg) - 30 days (Mean b, SD) | 2940 | 4133.0 | 2946.4 | 4374.0 |
| ADD (<= 4gm/day) - 30 days (n,%) | 1240 | 4.3% | 2819 | 3.3% |
| ADD (> 4gm/day) - 30 days (n,%) | 35 | 0.6% | 45 | 0.5% |
| Cumulative dose in the pre-index year | ||||
| Cumulative dose (gm) in the pre-index year (Mean b,SD) | 78.7 | 224.6 | 59.8 | 157.1 |
| Cumulative dose (<= 1kg) (n,%) | 6488 | 22.5% | 15734 | 18.2% |
| Cumulative dose (> 1kg) (n,%) | 49 | 0.2% | 75 | 0.1% |
| Duration of APAP use in the pre-index year | ||||
| Total days of APAP use (Mean c,SD) | 32.2 | 67.9 | 24.7 | 57.6 |
| Total days of APAP use (<= 30 days) (n,%) | 5309 | 18.4% | 13559 | 15.6% |
| Total days of APAP use (> 30 days) (n,%) | 1228 | 4.3% | 2250 | 2.6% |
| PMDD and Duration of APAP use in the pre-index year | ||||
| PMDD <= 4gm and total days <= 30 days (n,%) | 4002 | 13.9% | 10294 | 11.9% |
| PMDD <= 4gm and total days > 30 days (n,%) | 654 | 2.3% | 1161 | 1.3% |
| PMDD > 4gm and total days <= 30 days (n,%) | 1307 | 4.5% | 3265 | 3.8% |
| PMDD > 4gm and total days > 30 days (n,%) | 574 | 2.0% | 1089 | 1.3% |
| Types of APAP prescriptions for 22,346 APAP users | ||||
| Opioid/APAP combinations | 19740 | 93.5% | 39480 | 92.5% |
| Cough-cold products | 10 | 0.1% | 72 | 0.2% |
| Non-opioid combination analgesics | 1260 | 6.0% | 2924 | 6.9% |
| APAP only d | 97 | 0.5% | 226 | 0.5% |
ADD : Average daily dose; APAP : Acetaminophen; MDD : Maximum daily dose
a
mean values calculated for 798 cases and 1721 controls
b
mean values calculated for 1415 cases and 3271 controls
b
||,¶ mean values calculated for 6537 cases and 15809 controls
d
not significant at alpha = 0.05