Table 4.
Variable | No of cases |
No. of controls |
Unadjusted OR | Adjusted ORa (95% CI) |
P value |
---|---|---|---|---|---|
N = 28,892 |
N = 86,676 |
||||
APAP Exposure for at least one day in the 7 days pre-index | |||||
APAP exposure - 7 days | 798 | 1721 | 1.40 (1.29 – 1.53) | 1.02 (0.93 – 1.11) | 0.74 |
APAP Exposure for at least one day in the 30 days pre-index | |||||
APAP exposure - 30 days | 1415 | 3271 | 1.31 (1.23 – 1.40) | 0.97 (0.90 – 1.04) | 0.38 |
Maximum daily dose – 7 days preindex | |||||
MDD (<= 4gm) – 7 days | 690 | 1486 | 1.40 (1.28 – 1.54) | 1.03 (0.93 – 1.13) | 0.62 |
MDD (>4gm) – 7 days | 108 | 235 | 1.39 (1.11 – 1.74) | 0.96 (0.75 – 1.23) | 0.74 |
Maximum daily dose - 30 days preindex | |||||
MDD (<= 4gm) – 30 days | 1148 | 2632 | 1.32 (1.24 – 1.42) | 0.98 (0.90 – 1.05) | 0.53 |
MDD (>4gm) – 30 days | 267 | 639 | 1.27(1.10 – 1.46) | 0.94 (0.81 – 1.10) | 0.45 |
Average daily dose – 30 days preindex | |||||
ADD (<= 4gm) | 1240 | 2819 | 1.33 (1.25 – 1.43) | 0.98 (0.91 – 1.06) | 0.66 |
ADD (> 4gm) | 175 | 452 | 1.17 (0.99 – 1.40) | 0.88 (0.73 – 1.06) | 0.18 |
ADD : Average daily dose ; APAP : Acetaminophen ; MDD : Maximum daily dose ;
Analyses adjusted for (1) drug exposure variables (30 days pre-index) – antibiotics, non-steroidal anti-inflammatory drugs, beta blockers (2) diagnosis variables (365 days preindex) - eczema, rhinitis, chronic obstructive pulmonary disease, respiratory tract infections, gastrointestinal reflux disease, cancer (3) unmixed opioid-use in pre-index year and (4) health system variables – Medicare, Medicaid, Commercial health maintenance organization