Table 4.

Adjusted and Unadjusted Odds Ratios of Acute Acetaminophen Exposure (Reference Group: No APAP Exposure)

Variable	No of cases	No. of controls	Unadjusted OR	Adjusted ORa (95% CI)	P value
	N = 28,892	N = 86,676
APAP Exposure for at least one day in the 7 days pre-index
APAP exposure - 7 days	798	1721	1.40 (1.29 – 1.53)	1.02 (0.93 – 1.11)	0.74
APAP Exposure for at least one day in the 30 days pre-index
APAP exposure - 30 days	1415	3271	1.31 (1.23 – 1.40)	0.97 (0.90 – 1.04)	0.38
Maximum daily dose – 7 days preindex
MDD (<= 4gm) – 7 days	690	1486	1.40 (1.28 – 1.54)	1.03 (0.93 – 1.13)	0.62
MDD (>4gm) – 7 days	108	235	1.39 (1.11 – 1.74)	0.96 (0.75 – 1.23)	0.74
Maximum daily dose - 30 days preindex
MDD (<= 4gm) – 30 days	1148	2632	1.32 (1.24 – 1.42)	0.98 (0.90 – 1.05)	0.53
MDD (>4gm) – 30 days	267	639	1.27(1.10 – 1.46)	0.94 (0.81 – 1.10)	0.45
Average daily dose – 30 days preindex
ADD (<= 4gm)	1240	2819	1.33 (1.25 – 1.43)	0.98 (0.91 – 1.06)	0.66
ADD (> 4gm)	175	452	1.17 (0.99 – 1.40)	0.88 (0.73 – 1.06)	0.18

ADD : Average daily dose ; APAP : Acetaminophen ; MDD : Maximum daily dose ;

^aAnalyses adjusted for (1) drug exposure variables (30 days pre-index) – antibiotics, non-steroidal anti-inflammatory drugs, beta blockers (2) diagnosis variables (365 days preindex) - eczema, rhinitis, chronic obstructive pulmonary disease, respiratory tract infections, gastrointestinal reflux disease, cancer (3) unmixed opioid-use in pre-index year and (4) health system variables – Medicare, Medicaid, Commercial health maintenance organization