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. 2004 Apr 1;113(7):1040–1050. doi: 10.1172/JCI20465

Figure 7.

Figure 7

Anti-inflammatory effect of trapping VEGF-A. (A–C) Trapping of VEGF-A/PlGF using the molecular cytokine trap VEGF TrapR1R2 significantly reduces the recruitment of inflammatory cells into the cornea in the suture-induced neovascularization model. One week after surgery, control mice treated with Fc protein (Fc control) displayed a significant influx of inflammatory cells (IC and arrows) into the central corneal stroma (A). Trapping of VEGF-A significantly reduces this influx (B; and C, normal cornea). (D) Trapping of VEGF-A reduces stromal inflammatory cells by about 80% (P < 0.01). (E and F) The inflammatory cells found in the corneal stroma 7 days after suture placement and Fc treatment (controls) are overwhelmingly GR-1+ neutrophils (E, red) and less commonly, F4/80+CD11b+ macrophages (F, green). Magnification, ×100 (A–C) and ×400 (E and F).