Table 1.

Kinetic constants grouped by biosensor.

Manufacturer	Platform	n	ka (M−1 s−1)	kd (s−1)	KD (nM)
Biacore	A100	4	(1.1 ± 0.3) × 105	(0.60 ± 0.26) × 10−4	0.59 ± 0.35
	T100	33	(1.4 ± 0.8) × 105	(0.43 ± 0.14) × 10−4	0.36 ± 0.18
	S51	8	(1.7 ± 1.4) × 105	(0.86 ± 0.75) × 10−4	1.1 ± 1.2
	3000	77	(1.3 ± 0.9) × 105	(0.75 ± 1.2) × 10−4	0.83 ± 1.1
	2000	76	(1.4 ± 1.7) × 105	(0.57 ± 1.0) × 10−4	0.62 ± 1.2
	1000	2	(0.82 ± 0.19) × 105	(1.3 ± 0.7) × 10−4	1.8 ± 1.2
	X100	2	(1.26 ± 0.08) × 105	(0.38 ± 0.03) × 10−4	0.30 ± 0.01
	X	8	(0.87 ± 0.29) × 105	(0.65 ± 0.20) × 10−4	0.81 ± 0.28
	Flexchip	4	(1.2 ± 0.2) × 105	(0.46 ± 0.10) × 10−4	0.39 ± 0.13
Bio-Rad	ProteOn XPR36	21	(2.0 ± 1.0) × 105	(0.43 ± 0.25) × 10−4	0.25 ± 0.13
Reichert	SR7000 DC	9	(1.0 ± 0.4) × 105	(0.43 ± 0.44) × 10−4	0.46 ± 0.43
Akubio	RAPid 4	5	(1.1 ± 0.1) × 105	(0.58 ± 0.20) × 10−4	0.52 ± 0.14
ForteBio	Octet	3	(1.7 ± 0.6) × 105	(0.70 ± 0.22) × 10−4	0.45 ± 0.26
IBIS	iSPR	2	(4.4 ± 5.2) × 105	(0.78 ± 0.93) × 10−4	0.18 ± 0.35
GWC	SPRimager	1	0.41 × 105	42 × 10−4	100
Neosensors	IAsys	1	0.16 × 105	17 × 10−4	110
Nanofilm	EP3	1	0.54 × 105	3.1 × 10−4	5.7
Nomadics	SensiQ	1	1.72 × 105	0.27 × 10−4	0.16
Average		258	(1.4 ± 1.3) × 105	(0.61 ± 0.87) × 10−4	0.62 ± 0.98