Table 2.
C-TSK Unmasks the Ability of Host Cells to Induce Organizer
| Factor | Sample/Total | (%) |
|---|---|---|
| C-TSK | 0/8 | (0) |
| COS-7 + middle primitive streak | 4/24 | (17) |
| C-TSK + middle primitive streak | 17/29 | (59) |
|
| ||
| cVg1 + Wnt1 | 1/8 | (13) |
| C-TSK + cVg1 + Wnt1 | 6/15 | (40) |
|
| ||
| reCOS-7 + middle primitive streaka | 1/7 | (14) |
| noggin + middle primitive streaka | 12/22 | (55) |
| cVg1 + Wnt1a | 1/22 | (5) |
| noggin + cVg1 + Wnt1a | 7/27 | (26) |
The frequency of induction of organizer marker chordin by a graft of cells secreting the factors and tissue indicated is shown on the right. Note that C-TSK is able to unmask the ability of host cells to respond to node-inducing signals.
a
Stern’s group performed the same experiment with noggin as a BMP antagonist, though it is not expressed at this stage (Joubin and Stern, 1999).