Table 1.
Gene expression profiling shows significantly (P < 0.05) reduced expression of proto-oncogenes in MCF-7 cells stimulated with IGF-2 plus TCDD compared to cells stimulated with IGF-2 at 48 hrs after treatment (n = 3).
| Symbol | Description | P value | Fold regulation |
|---|---|---|---|
| E2F1 | E2F transcription factor 1 | 0.042684 | −4.0169 |
| CCND1 | Cyclin D1 | 0.007724 | −3.1767 |
| MYB | V-myb myeloblastosis viral oncogene homolog (avian) | 0.026054 | −3.1760 |
| SRC | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.027237 | −2.5269 |
| JAK2 | Janus kinase 2 | 0.028474 | −2.0015 |
| JUND | Jun D proto-oncogene | 0.026855 | −2.0066 |