Figure 2.

Target- and stimulus-specificity of the effects of oral tolerization on BALB/c bone marrow. BALB/c mice were orally preexposed to OVA ((a), (b)) or to the control antigens, BSA and HSA (c), before subcutaneous sensitization and airway challenge with OVA (open bars). Controls received only water before sensitization/challenge (black bars). Data (Mean ± SEM) are (a) EPO+ cell counts and (b) neutrophil counts, in freshly harvested bone marrow (n = 5) (*P ≤ 0.03); (c) EPO+ cell numbers in bone marrow cultured with 1 ng/mL IL-5 for 7 days (n = 3) (*P ≤ 0.001).