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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Mod Pathol. 2012 Aug 24;26(1):131–138. doi: 10.1038/modpathol.2012.138

Figure 1.

Figure 1

Immunohistochemical staining showing scanty MSH6 staining in a colonic adenocarcinoma; a and b represent two areas from one tumor where there is distinct nuclear staining for MSH6, but the staining is present only in a limited number of tumor cells. Note the presence of tumor-infiltrating lymphocytes that stain positively for MSH6. This tumor has intact expression of MSH2 and complete loss of MLH1 and PMS2 (staining not shown).