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Immunohistochemical staining for DNA mismatch repair proteins in a rectal adenocarcinoma that has undergone neoadjuvant treatment. (a) Illustration of an area of residual carcinoma present as widely spaced tumor glands in the muscularis propria. By immunohistochemistry, these glands show focal positive staining for MSH6 (b); elsewhere the tumor is negative for MSH6 (staining not shown). This tumor has intact expression of MSH2 (c), MLH1 (d) and PMS2 (staining not shown).
