Table 2.

hMSH3 downregulation pattern in hypoxia in human cell lines derived from various origins.

Cell line	Origin	p53 Status	mRNA level, %a		Down-regulation pattern
			Day 1	Day 3
HCT116+5	colorectal cancer	wild type	77.2	33.3b *	Rapid
HCT116+3+5	colorectal cancer	wild type	80.9	41.5*	Rapid
HEK293	embryonic kidney	wild type	ntc	32.6*	Rapid
SW480	colorectal cancer	mutant	76.9	68.8*	Moderate
SW620	colorectal cancer	mutant	73.8	75.3b*	Moderate
colo320DM	colorectal cancer	mutant	nt	73.8	Moderate
HeLa S3	cervix carcinoma	mutant	nt	79.4*	Moderate
TGW	neuroblastoma	mutant	nt	69.5*	Moderate
GOTO	neuroblastoma	wild type	107.5	96.2	No
MCF-7	breast adenocarcinoma	wild type	103.6	100.6	No

^*P<0.05

^aPercentage of the relative mRNA amount in hypoxia was determined by the following formula: Ct at hypoxia/Ct at normoxia×100.

^bThe mRNA level was determined at day 2 in hypoxia.

^cnt: not tested.