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p53-dependent down-regulation of hMSH3 mRNA by hypoxia.
| Cell | p53 Status | Reduction of hMSH3 mRNA, % | P value |
|---|---|---|---|
| SW480+pCEP4 | mutant | 51.8 | 0.003 |
| SW480+pXZ53 | mutant+wild type | 64.8 | |
| HCT116+5 | wild type | 66.8 | 0.01 |
| null-p53 HCT116+5 | null | 32.7 | |
| null-p53 HCT116+5+pCEP4 | null | 40.0 | 0.007 |
| null-p53 HCT116+5+pXZ53 | null+wild type | 57.0 |
The hMSH3 mRNA was quantified by qRT-PCR. P values were determined by Student t-test.
