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. 2013 Oct 4;7:1089–1102. doi: 10.2147/DDDT.S48971

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© 2013 Zhang et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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Effect of DRz concentration on the expression of IGF-IIP3 in SMMC-7721 cells.

Notes: (A) mRNA expression of IGF-IIP3 was significantly inhibited by different concentrations of DRzs (1 μg/mL = 0.098 pmol/μL). The cells were transfected with the indicated concentrations of DRz1, DRz2, or DRz1^inv for 24 hours. Data shown are means ± SD of normalized relative IGF-IIP3 mRNA levels (n ≥3). *Significant difference to control (P < 0.05); (−) dimensionless units. (B) IGF-IIP3 protein expression was quantified via densitometry and compared with the “no treatment” control. The maximal gray value was set to 1 and all other results are expressed relative to this value (black) (n ≥3).

Abbreviations: DRz, deoxyribozyme (DNAzyme); DRz1^inv, inactive DRz; IGF-IIP3, insulin-like growth factor II promoter 3; mRNA, messenger RNA; SD, standard deviation.