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. 2013 Nov;54(11):3016–3029. doi: 10.1194/jlr.M038273

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Copyright © 2013 by the American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 6. — Effects of KYC on MPO-mediated LDL oxidation. LDL oxidation was induced by MPO (20 nM), H₂O₂ (100 μM), and NaNO₂ (100 μM) in phosphate buffer (100 mM, pH 7.4) containing DTPA (100 μM) at room temperature. A: KYC dose-dependently inhibits LDL lipid oxidation induced by MPO/H₂O₂/NaNO₂. Line graphs showing time- and concentration-dependent oxidation of LDL. KYC decreases MPO-mediated oxidation as measured by absorbance of conjugated dienes at 234 nm. B: Effects of 25 μM KYC, KYS, and KFC on MPO/H₂O₂/NaNO₂-mediated LDL conjugated diene formation. C: Effects of KYC, GSH, Tyr, and Trp (25 μM) on MPO/H₂O₂/NaNO₂-mediated LDL conjugated diene formation. D: Effects of KYC, GSH, Tyr, and Trp (25 μM) on MPO/H₂O₂-induced LDL conjugated diene formation. Incubation conditions were the same as above in (B) except without NaNO₂ as outlined in Materials and Methods. E: MPO-mediated LDL MDA formation determined by N-methyl-2-phenylindole assay at 586 nm. The data represent three independent experiments.