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Activation of RAGE shedding at therapeutically relevant statin concentrations. HEK/RAGE cells were treated with a nanomolar concentration of lovastatin, fluvastatin, and atorvastatin as indicated. As a control, cells were treated with equivalent amounts of solvent. Experiments were performed and analyzed as described in Fig. 2. Shown are the mean effects ± SD. Significance was determined by the one-way ANOVA Bonferroni test (**P < 0.01, ***P < 0.001).
