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Epimerization reaction from CDCA to UDCA, which is catalyzed by the 7α-HSDH and 7β-HSDH enzymes. The 7β-HSDH from R. gnavus N53 preferentially catalyzes the UDCA-forming reaction (reductive reaction) as compared with the 7-oxo-LCA-forming reaction (oxidative reaction), which is denoted by the thickness of the arrow lines.
