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(A) Chemical structures of compounds used in this study, with PGE2 provided for comparison. (B) The currently elucidated COX-2/15-LOX- and 15-PGDH-dependent pathway for generation of 11-oxo-ETE and 15-oxo-ETE. 15-LOX, 15-lipoxygenase; cPLA2, cytosolic phospholipase A2; DH, dehydrogenase; PGH2, prostaglandin H2; POX, peroxidase.
