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. 2013 Nov;54(11):3198–3205. doi: 10.1194/jlr.P042077

TABLE 4.

Lipid loci showing evidence of two signals in the CLHNS

Locus	Trait	SNP	Mothers (n = 1,782)			Offspring (n = 1,719)			Combined		LD (D′/r²)^c
Locus	Trait	SNP	EAF	P_initial^a	P_conditional^b	EAF	P_initial^a	P_conditional^b	P_initial^a	P_conditional^b	LD (D′/r²)^c
APOA5	TGs	rs662799	0.76	3.1E-18	2.5E-15	0.73	2.6E-10	7.7E-07	5.7E-24	1.1E-17	1.00/0.09
APOA5	TGs	rs3741297	0.98	3.1E-06	7.4E-03	0.97	3.5E-08	1.1E-04	3.2E-12	1.1E-05	1.00/0.09
CETP	HDL-C	rs1800775	0.40	6.3E-07	1.1E-04	0.43	1.7E-04	0.013	3.4E-09	1.2E-05	0.64/0.06
CETP	HDL-C	rs7499892	0.84	1.9E-06	3.1E-04	0.84	4.1E-09	2.4E-07	3.5E-12	1.1E-08	0.64/0.06
LIPC	HDL-C	rs588136	0.69	5.1E-06	1.0E-04	0.63	1.1E-09	2.0E-07	1.5E-12	1.6E-09	0.34/0.06
LIPC	HDL-C	rs1532085	0.43	2.6E-04	6.1E-03	0.46	4.1E-05	6.0E-03	5.8E-07	4.5E-04	0.34/0.06
APOE	LDL-C	rs7412	0.12	1.6E-27	5.9E-28	0.11	1.0E-35	2.6E-33	2.7E-53	5.4E-52	1.00/0.01
APOE	LDL-C	rs769449	0.91	0.032	0.015	0.91	1.5E-08	4.4E-06	5.0E-07	1.5E-05	1.00/0.01

Results are shown for SNPs with P_initial < 10⁻⁶ in the CLHNS mother and offspring combined cohort. EAF, effect allele frequency.

^a

P_initial: P values for main effect association.

^b

P_conditional: P values produced by reciprocal conditional analyses, in which both the primary and secondary signals were included in the model.

^c

LD (D′/r²) between the secondary and primary signals (shown in Tables 2, 3) was estimated based on Metabochip genotypes in the 1,719 CLHNS offspring.