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. Author manuscript; available in PMC: 2014 Jan 28.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Dec 11;52(5):1472–1476. doi: 10.1002/anie.201207063

Figure 1.

Figure 1

Modification of cell membranes with aptamers. (a) Schematic representation of targeting cancer cells (blue) with aptamer-modified immune cells (red). After incubating with lipo-aptamer probes (shown in expansion), immune cells recognize cancer cells in the cell mixture, and kill cancer cells. (b) Confocal microscope image of lipo-Lib-TMR-treated CEM cells. Red fluorescent probes were found only on the cell surface. Scale bar: 10 µm. (c) CEM cells were treated with lipo-Lib-FITC for different time intervals in cell culture medium. The maximum insertion was reached in 2 hours. (d) Ramos cells spontaneously aggregate after treatment with lipo-TD05-TMR. Scale bar: 100 µm. (e) Control experiments showed no assembly when Ramos cells were treated with lipo-lib-TMR. Scale bar: 100 µm.