Table 2.
LOH Patterns in Prospective Cohort and Retrospective Cohort
| Study | LOH Patterns‡ | All patients | Non-Progressing Cases | Progressing cases | Hazard Ratio (95% CI) | P Value | |
|---|---|---|---|---|---|---|---|
| Prospective Cohort | 296 | 255 (86·1)† | 41 (13·9) | ||||
| Presence of LOH# | |||||||
| No LOH | 35 | 35 (100·0) | 0 (0·0) | 1 | |||
| Any LOH | 252 | 211 (83·7) | 41 (16·3) | NA | |||
| 3p and 9p | |||||||
| 3p & 9p R | 100 | 99 (99·0) | 1 (1·0) | 1 | 0·002 | ||
| 3p &/or 9p LOH | 191 | 152 (79·6) | 39 (20·4) | 22·6 (3·1-164·5) | |||
| 9p | |||||||
| 9p R | 130 | 128 (98·5) | 2 (1·5) | 1 | <0·001 | ||
| 9p LOH | 161 | 124 (77·0) | 37 (23·0) | 17·0 (4·1-70·8) | |||
| 3p | |||||||
| 3p R | 185 | 163 (88·1) | 22 (11·0) | 1 | 0·48 | ||
| 3p LOH | 106 | 90 (84·9) | 16 (15·1) | 1·3 (0·7-2·4) | |||
| Retrospective Cohort | 116 | 87(75·0) | 29 (25·0) | ||||
| Presence of LOH# | |||||||
| No LOH | 36 | 36 (100·0) | 0 (0·0) | 1 | |||
| Any LOH | 68 | 39 (57·4) | 29 (42·6) | NA | |||
| 3p and 9pҸ | |||||||
| 3p & 9p R | 49 | 48 (98·0) | 1 (2·0) | 1 | 0·003 | ||
| 3p &/or 9p LOH | 60 | 32 (53·3) | 28 (46·7) | 21·1 (2·9-155·8) | |||
| 9p | |||||||
| 9p R | 66 | 59 (89·4) | 7 (10·6) | 1 | 0·002 | ||
| 9p LOH | 47 | 25 (53·2) | 22 (46·8) | 3·8 (1·6-8·9) | |||
| 3p | |||||||
| 3p R | 74 | 64 (86·5) | 10 (13·5) | 1 | <0·001 | ||
| 3p LOH | 36 | 18 (50·0) | 18 (50·0) | 3·9 (1·8-8·4) | |||
†
Row percentage is reported.
‡
LOH, loss of heterozygosity; R, retention (no LOH); NI, non-informative. Due to NI, total numbers of cases for each reported LOH pattern may not add up to the total number of subjects.
#
For the “No LOH” category, subjects need to have retention in all chromosome arms tested. For the “Any LOH” category, subjects can have some chromosome arms to be non-informative as long as at least one chromosome arm was LOH.
Ҹ
Ref. 7. Values in the Table differ slightly from original publication due to additional analyses of samples since publication of study. The previous publication included 7 cases that we categorised as low-or high-risk with NI on either 3p or 9p.