Table 3.

Cox Proportional Hazards Models on Time to Progression

Analysis	Variable	Prospective Cohort (N = 296)			Retrospective Cohort (N = 116)
		HR (95% CI)	P value	C-index (95% CI)	HR (95% CI)	P value	C-index (95% CI)
A. Previous Models
Model 1	3p &/or 9p LOH†	22·6 (3·1-164·5)	0·002	0·66 (0·47, 0·81)	21.1 (2·9-155·8)	0·003	0·70 (0·48, 0·86)
Model 2	3p &/or 9p LOH	18·5 (2·5-135·3)	0·004		14·4 (1·9-111·7)	0·01
	High-risk site	2·5 (1·2-5·6)	0·02	0·75 (0·56, 0·87)	1·9 (0·8-4·7)	0·16	0·77 (0·53, 0·91)
	Non-smoker	1·8 (1·0-3·4)	0·06		1·8 (0·8-4·2)	0·17
B. Current Models
Model 3	Intm-risk LOH*	11·6 (2·7-49·9)	0·001	0·79 (0·59, 0·91)	3·4 (1·4-8·2)	0·006	0·68 (0·46, 0·84)
	High-risk LOH‡	52·1 (11·8-230·6)	<0·001		11·2 (3·3-38·6)	<0·001
Model 4	Intm-risk LOH*	9·7 (2·2-42·0)	0·003		3·2 (1·1-9·4)	0·04
	High-risk LOH‡	41·7 (9·3-187·6)	<0·001	0·81 (0·61, 0·92)	7·6 (1·8-32·6)	0·007	0·75 (0·51, 0·90)
	High-risk site	1·8 (0·8-4·0)	0·16		2·2 (0·8-5·7)	0·12
	Non-smoker	2·0 (1·0-3·8)	0·05		1·7 (0·7-4·1)	0·21

^†High-risk LOH: (3p &/or 9p LOH) compared to Low-Risk (3p and 9p R).

^*Intm-R (Intermediate-risk LOH): (9pLOH only or with either 17pLOH or 4qLOH but not both) compared to Low-Risk (9pR).

^‡High-risk LOH: (9pL and 4qL and 17pL).