Table 2.
Results of VHL mutation analysis in original tumors and corresponding xenografts.
| Case n. |
Histologica Diagnosis |
Tissue type | VHL Mutation |
Exon | Mutation Type |
Codon and predicted aa change* |
|---|---|---|---|---|---|---|
| 3 | cRCC | Original | Yes | 1 | FS | N67fsX158 |
| Xenograft | Yes | 1 | FS | N67fsX158 | ||
| 5 | cRCC | Original | Yes | 1 | MS | V74G |
| Xenograft | Yes | 1 | MS | V74G | ||
| 6 | cRCC | Original | Yes | 1 | NS & MS | S65X & R64S |
| Xenograft | Yes | 1 | NS & MS | S65X & R64S | ||
| 8 | cRCC | Original | Yes | 3 | MS | L158R |
| Xenograft | Yes | 3 | MS | L158R | ||
| 9 | cRCC | Original | Yes | 2 | FS | F136fsX158 |
| Xenograft | Yes | 2 | FS | F136fsX158 | ||
| 10 | cRCC | Original | No | - | - | - |
| Xenograft | No | - | - | - | ||
| 11 | pRCC | Original | No | - | - | - |
| Xenograft | No | - | - | - | ||
| 12 | cRCC | Original | Yes | 3 | FS | L158fsX169 |
| Xenograft | Yes | 3 | FS | L158fsX169 | ||
| 13 | cRCC | Original | Yes | 2 | FS | L135fsX158 |
| Xenograft | Yes | 2 | FS | L135fsX158 | ||
| 19 | cRCC | Original | No | - | - | - |
| Xenograft | No | - | - | - |
*
aa: aminoacids