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. Author manuscript; available in PMC: 2014 Jul 10.
Published in final edited form as: Gene. 2013 Apr 8;523(2):137–146. doi: 10.1016/j.gene.2013.02.050

Fig. 3.

Fig. 3

Loss of a splice donor site in CFTR exon14led to the capture of formerly intronic sequence as R domain coding sequence. (A) Amino acid sequence alignment for the region centered on the ancestral ABCC4 splice donor site and the corresponding exon 14 extension in CFTR. (B & C) ABCC4 (red) and CFTR (blue) nucleotide sequence conservation levels for the same region. (D) Sequence motifs representing the site-specific sequence variation for canonical human splice site donor sequences, the ABCC4 exon 14 splice site donor sequence, and the corresponding region in CFTR. (E) Nucleotide sequence alignment for the region corresponding to the ABCC4 ancestral splice donor site and the CFTR exon 14 extension.