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. 2013 Sep 19;126(Pt 2):155–162. doi: 10.1042/CS20130101

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© 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A–C) PDs of MCh were calculated for individual dose–response curves, examples of which are shown for ΔC_dyn (A), ΔEF₅₀ (B) and ΔR_L (C) in naïve marmosets (R²=0.98, 0.87 and 0.92). Logarithmic MCh values were reversed to obtain PDs. (D) PDs of MCh required to increase R_L 50, 100 and 150% above baseline in naïve animals and 18 h after LPS administration. Results are means±S.E.M., n=10 for PD₅₀ and PD₁₀₀ and n=9 for PD₁₅₀; paired Student's t test.