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. 2013 Sep 19;126(Pt 2):155–162. doi: 10.1042/CS20130101

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© 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) An overview of one complete measurement. From below: photometer signals for applied MCh doses (0.5, 1, 2 and 4 μg). For increasing MCh doses P_oes (cmH₂O) increased, whereas C_dyn (ml/cmH₂O) decreased and R_L (cm H₂O·s·ml⁻¹) increased simultaneously. At the end of record, a puff of salbutamol caused a decreasing P_oes, increasing C_dyn and falling R_L. (B) Segment (17 s) of one measurement with individual breaths visible after application of 1 μg of MCh. P_oes (cmH₂O) on top and airflow (ml/s) below (snapshots from Notocord-hem™ software; *artefact, manipulation of the orotracheally intubated animal for salbutamol administration).