Table 1. NMR data and refinement statistics.

NMR distance and dihedral constraints
Distance restraints:
Total NOE	1476
Intra-residual	388
Sequential (|i–j|  = 1)	378
Medium-range (2≤ |i–j| ≤4)	281
Long-range (|i–j| >4)	429
Hydrogen bonds	14
Zinc-ligand distance restraints	23
Dihedral Angle restraints:
φ	61
ψ	61

^aValues calculated for the ordered regions, as reported by PSVS [26]: residues 118–183.

^br.m.s.d calculated for residues 118–183.

^cCalculated by PSVS.

^dRPF scores [27] reflecting the goodness-of-fit of the structural ensemble to the NMR data.