Table 3. Association of MS susceptibility genes with attack severity and recovery (multivariate models).
Gene | More severe attacks | Worse recovery from attacks |
RGS1 | 0.47 (0.21, 1.03), p = 0.060 | 0.96 (0.29, 3.18), p = 0.94 |
CD6 | 1.01 (0.76, 1.33), p = 0.96 | 1.25 (0.93, 1.68), p = 0.13 |
MPHOSPH9 | 1.47 (1.11, 1.94), p = 0.008 | 1.05 (0.78, 1.41), p = 0.77 |
TNFRSF1A | 0.63 (0.40, 1.00), p = 0.050 | 0.77 (0.44, 1.34), p = 0.35 |
HLA-DRB1 | 0.95 (0.71, 1.28), p = 0.74 | 1.10 (0.82, 1.48), p = 0.52 |
CD58 | 0.43 (0.10, 1.84), p = 0.25 | 0.54 (0.11, 2.64), p = 0.45 |
EVI5 | 0.97 (0.72, 1.30), p = 0.83 | 1.22 (0.90, 1.65), p = 0.20 |
KIF21B | 1.04 (0.58, 1.87), p = 0.89 | 1.11 (0.50, 2.48), p = 0.80 |
IL12A | 1.16 (0.87, 1.55), p = 0.32 | 1.03 (0.77, 1.37), p = 0.85 |
TMEM39A | 0.82 (0.21, 3.24), p = 0.78 | 0.90 (0.39, 2.11), p = 0.82 |
IL7R | 0.91 (0.48, 1.73), p = 0.77 | 0.80 (0.41, 1.59), p = 0.53 |
IL2RA | 1.19 (0.63, 2.26), p = 0.59 | 1.38 (0.61, 3.14), p = 0.44 |
CLEC16A | 1.28 (0.79, 2.09), p = 0.32 | 0.99 (0.64, 1.52), p = 0.96 |
CD226a | 1.09 (0.78, 1.53), p = 0.60 | 1.08 (0.78, 1.51), p = 0.64 |
TYK2 | 0.86 (0.50, 1.48), p = 0.59 | 1.00 (0.50, 2.01), p = 0.99 |
IRF8 | 0.94 (0.38, 2.31), p = 0.89 | 0.62 (0.24, 1.61), p = 0.32 |
GPC5 | 1.03 (0.77, 1.39), p = 0.83 | 1.06 (0.79, 1.44), p = 0.69 |
Results are presented as odds ratios (95% confidence intervals), p values.