Table 4. Association of MS susceptibility genes with occurrence of second event (multivariate models).

Gene	Second event (OR) within a year*	Risk (HR) of second event**
CD58	0.66 (0.17, 2.63), p = 0.56	0.53 (0.26, 1.09), p = 0.082
IL7R	1.88 (0.73, 4.88), p = 0.19	1.41 (0.82, 2.41), p = 0.22
TNFRSF1A	1.61 (0.82, 3.18), p = 0.17	1.29 (0.88, 1.90), p = 0.19
GPC5	1.31 (0.88, 1.95), p = 0.19	0.95 (0.75, 1.20), p = 0.65
HLA-DRB1	1.10 (0.74, 1.62), p = 0.65	1.02 (0.81, 1.29), p = 0.88
RGS1	0.57 (0.16, 1.96), p = 0.37	0.90 (0.39, 2.06), p = 0.80
EVI5	1.09 (0.72, 1.64), p = 0.69	1.08 (0.85, 1.38), p = 0.53
KIF21B	1.02 (0.44, 2.34), p = 0.96	0.97 (0.59, 1.60), p = 0.92
IL12A	0.77 (0.52, 1.15), p = 0.20	1.03 (0.82, 1.31), p = 0.78
TMEM39A	0.56 (0.12, 2.71), p = 0.47	1.17 (0.47, 2.91), p = 0.74
IL2RA	0.81 (0.31, 2.14), p = 0.67	1.05 (0.60, 1.85), p = 0.87
CD6	0.82 (0.55, 1.21), p = 0.31	1.04 (0.82, 1.31), p = 0.77
MPHOSPH9	0.89 (0.60, 1.32), p = 0.56	0.99 (0.78, 1.24), p = 0.91
CLEC16A	1.20 (0.63, 2.31), p = 0.58	0.80 (0.55, 1.16), p = 0.24
CD226a	1.00 (0.64, 1.54), p = 0.99	1.02 (0.79, 1.32), p = 0.88
TYK2	1.14 (0.46, 2.86), p = 0.78	1.14 (0.67, 1.93), p = 0.63
IRF8	1.33 (0.41, 4.32), p = 0.63	1.28 (0.67, 2.45), p = 0.45

^*missing 4 and **44 ONTT patients.

Results are presented as odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals, p values.