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. 2013 Oct 10;7:176. doi: 10.3389/fncel.2013.00176

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Copyright © Fang, Li, Flammer and Neutzner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inactivation of MARCH5 blunts ROS production under neurodegenerative stress conditions. (A) SH-SY5Y cells expressing mitoYFP, MARCH5-YFP, or MARCH5^H43W-YFP were treated with the ROS-sensitive dye CellROX and intracellular ROS levels were measured using image analysis of confocal pictures. SH-SY5Y cells expressing MARCH5-YFP or MARCH5^H43W-YFP were treated with 75 μM 6-hydroxydopamine for 6 h (B), 5 μM rotenone for 6 h (C), or 25 μMAβ peptide for 24 h (D) and mitochondrial membrane potential was measured as in (A). Shown is the average of four independent experiments with 10 cells per condition. Statistical significance was analyzed using Student’s t-test with ** marking p < 0.01 and n.s. marking no significant difference. Error bars represent SEM.