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CCMT-increased ank expression leads to ePPi generation. Contribution of ank to transforming CCMT-induced increase in extracellular inorganic pyrophosphate (ePPi) production. The effect of small interfering RNA (siRNA) on Ank mRNA levels (A). The effect of ank on ePPi levels (B). Data showed siRNA (ank) down-regulated CCMT-induced ePPi expression (B). All experiments were repeated at least three times. The columns represent the mean ± SE. *P<0.05, **P<0.01 vs nonloading.
