Table 1. Clinical characteristics of patients with asthma.
| CHARACTERISTICS | ALL PATIENTS | ATOPIC | NON-ATOPIC | EVER - SMOKERS | NON-SMOKERS | ICS ALONE recipients | ICS + LABA recipients | p-value4 |
|---|---|---|---|---|---|---|---|---|
| Subjects, n (%) | 208 | 90 (43) | 118 (57) | 53 (25.4) | 155 (74.6) | 121(58) | 87(42) | |
| Age, years, mean (SD) | 43 (14) | 36 (13) | 49 (12) | 44 (14) | 43 (15) | 42 (15) | 45 (13) | |
| Male sex, n (%) | 70 (43) | 41 (46) | 29 (24) | 25 (47) | 45 (29) | 31 (26) | 39 (45) | |
| %PREDICTED FEV1, median (IQR) | ||||||||
| At baseline | 84 (18) | 88 (19) | 83 (20) | 79 (17) | 87 (19) | 88 (15) | 76 (21) | |
| Change after 3 months of treatment 1 | 5 (9) | 5 (10) | 6 (9) | 5 (7) | 5 (9) | 4 (9) | 6 (9) | <0.0001 |
| Change after > 3 years of treatment 1 | 4 (9) | 4 (11) | 4 (8) | 4 (9.5) | 4 (9) | 4 (6.5) | 5 (11) | <0.0001 |
| PD20 mg at baseline, median (IQR) | 0.65 (1.09) | 0,56 (1.10) | 0.69 (1.09) | 0.48 (0.87) | 0.71 (1.20) | 1.00 (1.41) | 0.44 (0.73) | |
| PD20 mg change after > 3 years of treatment, median (IQR) 2 | 1.20 (2.35) | 1.27 (0.52) | 1.16 (2.13) | 1.07 (2.48) | 1.21 (2.36) | 1.27 (2.05) | 0.91 (2.83) | <0.0001 |
| ACT at baseline, median (IQR) | 13 (7) | 15 (8) | 12 (5) | 11.5 (6.25) | 13 (8) | 14 (8) | 12 (7) | |
| ACT, change after > 3 years of treatment, median (IQR) 3 | 7 (6) | 7 (6.5) | 8 (5) | 7 (5) | 7 (5) | 7 (6) | 7 (6) | <0.0001 |
| AQLQ at baseline, median (IQR) | 117 (61.5) | 125 (67) | 111 (54) | 110 (59.5) | 119 (61) | 118 (67) | 112 (58) | |
| AQLQ, change after > 3 years of treatment, median (IQR) 3 | 51 (46.5) | 50 (53.5) | 51 (40) | 52 (54.5) | 51 (44) | 51 (46) | 51 (52) | <0.0001 |
1The change from baseline in the % predicted FEV1 after 3 months and after > 3 years of treatment.
2The change from baseline PD20 in mg after > 3 years of treatment.
3The change in ACT questionnaire and in AQLQ questionnaire scores after > 3 years of treatment.
4Significance of changes from baseline for the entire group of 208 patients (Wilcoxon matched-pairs signed rank test).