Table 2. TBX21 rs9910408 genotype frequencies in good and poor responders after > 3 years of treatment.
| Response | TBX21 rs9910408 genotype | ALL PATIENTS (n, %) | ATOPIC (n, %) | NON-ATOPIC(n, %) | SMOKERS (n, %) | NON-SMOKERS (n, %) | ICS ALONE recipients (n, %) | ICS + LABA recipients (n, %) | |
|---|---|---|---|---|---|---|---|---|---|
| % FEV1 change | good | AA | 65 (37.8) | 27 (38.0) | 38 (37.6) | 12 (26.7) | 53 (41.7) | 37 (39.8) | 28 (35.4) |
| AG | 89 (51.7) | 33 (46 5) | 56 (55.4) | 26 (57.8) | 63 (49.6) | 45 (48.4) | 44 (55.7) | ||
| GG | 18 (10.5) | 11 (15.5) | 7 (7.0) | 7 (15.5) | 11 (8.7) | 11 (11.8) | 7 (8.9) | ||
| poor | AA | 8 (22.2) | 6 (31.6) | 2 (11.8) | 3 (37.5) | 5 (17.9) | 7 (25.0) | 1 (12.5) | |
| AG | 22 (61.1) | 10 (52.6) | 12 (70.6) | 5 (62.5) | 17 (60.7) | 16 (57.1) | 6 (75.0) | ||
| GG | 6 (16.7) | 3 (15.8) | 3 (17.6) | 0 (0.0) | 6 (21.4) | 5 (17.9) | 1 (12.5) | ||
| PD20 change | good | AA | 51 (40.5) | 23 (39.0) | 28 (41.8) | 8 (23.5) | 43 (46.7) | 28 (41.8) | 23 (39.0) |
| AG | 64 (50.8) | 27 (45.8) | 37 (55.2) | 21 (61.8) | 43 (46.7) | 31 (46.3) | 33 (55.9) | ||
| GG | 11 (8.7) | 9 (15.2) | 2 (3.0) | 5 (14.7) | 6 (6.6) | 8 (11.9) | 3 (5.1) | ||
| poor | AA | 22 (26.8) | 10 (32.3) | 12 (23.5) | 7 (36.9) | 15 (23.8) | 16 (29.6) | 6 (21.4) | |
| AG | 47 (57.3) | 16 (51.6) | 31 (60.8) | 10 (52.6) | 37 (58.7) | 30 (55.6) | 17 (60.7) | ||
| GG | 13 (15.9) | 5 (16.1) | 8 (15.7) | 2 (10.5) | 11 (17.5) | 8 (14.8) | 5 (17.9) | ||
| ACT score change | good | AA | 61 (34.3) | 24 (32.9) | 37 (35.2) | 12 (26.1) | 50 (37.9) | 37 (34.9) | 24 (33.3) |
| AG | 98 (55.0) | 37 (50.7) | 61 (58.1) | 29 (63.0) | 68 (51.5) | 55 (51.9) | 43 (59.7) | ||
| GG | 19 (10.7) | 12(16.4) | 7 (6.7) | 5 (10.9) | 14 (10.6) | 14 (13.2) | 5 (7.0) | ||
| Poor | AA | 12 (40.0) | 9 (52.9) | 3 (23.1) | 3 (42.8) | 9 (39.1) | 7 (46.7) | 5 (33.3) | |
| AG | 13 (43.3) | 6 (35.3) | 7 (53.8) | 2 (28.6) | 11 (47.8) | 6 (40.0) | 7 (46.7) | ||
| GG | 5 (16.7) | 2 (11.8) | 3 (23.1) | 2 (28.6) | 3 (13.1) | 2 (13.3) | 3 (20.0) | ||
| AQLQ score change | good | AA | 68 (36.4) | 28 (36.4) | 40 (36.4) | 13 (27.1) | 55 (39.6) | 41 (36.9) | 27 (35.5) |
| AG | 100 (53.5) | 38 (49.3) | 62 (56.4) | 30 (62.5) | 70 (50.3) | 56 (50,5) | 44 (57.9) | ||
| GG | 19 (10.1) | 11 (14.3) | 8 (7.2) | 5 (10.4) | 14 (10.1) | 14 (12.6) | 5 (6.6) | ||
| poor | AA | 5 (23.8) | 5 (38.5) | 0 (0.0) | 2 (40.0) | 3 (18.7) | 3 (30.0) | 2 (18.2) | |
| AG | 11 (52.4) | 5 (38.5) | 6 (75.0) | 1 (20.0) | 10 (62.6) | 5 (50.0) | 6 (54.5) | ||
| GG | 5 (23.8) | 3 (23.0) | 2 (25.0) | 2 (40.0) | 3 (18.7) | 2 (20.0) | 3 (27.3) |