Figure 1.

Anterior cortical midline findings of previous studies reporting self-related abnormalities in depression. Spheres are centered on peak voxel values of regions whose activities are reported significantly different in major depressive patients from healthy control subjects during self-referential processing, or during another paradigm (e.g., rest or emotional face processing) where activity was associated with rumination scores. Talairach coordinates were converted into MNI space with BrainMap toolbox (brainmap.org). Activity is greater in patients than control subjects unless otherwise indicated. *With a remitted patient sample. **Hypoactivity in patients.