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. Author manuscript; available in PMC: 2013 Oct 10.
Published in final edited form as: Int J Cancer. 2011 Feb 15;128(4):869–878. doi: 10.1002/ijc.25422

Figure 2.

Figure 2

Constitutional MLH1 methylation in somatic tissues of Proband BF. (a) Bisulfite pyrosequencing in peripheral blood lymphocytes (PBL) and other somatic tissues in BF show soma-wide mosaic methylation of the MLH1 “Deng-C” region. The sequence analyzed is written above the peaks within each pyrogram. Vertical gray bars indicate the position of the C/T (Y) nucleotides within the five CpG sites interrogated for methylation status. The level of methylation C:T at each site is given in the boxes above, with the average methylation score of the five CpG sites provided at the top of each pyrogram. The vertical yellow bar indicates a control for complete bisulphite conversion. (b) Clonal bisulfite sequencing within the MLH1-C region shows the allelic pattern of methylation. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]