. Author manuscript; available in PMC: 2013 Oct 10.

Published in final edited form as: J Clin Psychopharmacol. 2012 Dec;32(6):787–796. doi: 10.1097/JCP.0b013e3182726764

TABLE 5.

Comparison Between Change in Alcohol Use Parameters in Antidepressant Responders and Nonresponders to Each Intervention (ITT Sample Based on LOCF)

	Acamprosate		Placebo

	Responders (Mean ± SD)	Nonresponders (Mean ± SD)	Responders (Mean ± SD)	Nonresponders (Mean ± SD)
Days in treatment	74 ± 22^*	29 ± 32^*	60 ± 30	32 ± 31
Change in Drinks/drinking day	−1 ± 1	−1 ± 1	−1 ± 1	1 ± 2
Change in drinks/wk	−4 ± 6	−8 ±6	0 ± 0	−7 ± 15
Change in drinks/mo	−18 ± 25	−32 ± 24	−2 ± 2	−28 ± 61
Change in percent days abstinent	−1 ± 12	−27 ± 42	−1 ± 3	9 ± 18

Statistically significant difference between acamprosate responders and nonresponders: t = −2.84, P = 0.018; Mann-Whitney: U = 5.0, Z = −2.10, P = 0.036.

All other comparisons between responders and nonresponders were nonsignificant.